Search on: COMPLEMENT C3-C5 CONVERTASES 
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Descriptor English:   Complement C3-C5 Convertases 
Descriptor Spanish:   Convertasas de Complemento C3-C5 
Descriptor Portuguese:   Convertases de Complemento C3-C5 
Synonyms English:   C3 Convertase  
Tree Number:   D12.776.124.486.274.045.387
Definition English:   Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue. 
Pharmacological Action:   Immunologic Factors
 
History Note English:   2006 (1978) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification CT contraindications
DF deficiency DU diagnostic use
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   50828 
Unique Identifier:   D050577 

Occurrence in VHL: 		 

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